Diffuse cerebrospinal gliomatosis mimicking amyotrophic lateral sclerosis

We present a case in which the clinical manifestations mimicked amyotrophic lateral sclerosis (ALS) and the pathological findings showed diffuse cerebrospinal gliomatosis. Diffuse cerebrospinal gliomatosis may be disguised as ALS when it predominantly involves the spinal cord and brain stem, and may not be easily differentiated from ALS. Therefore, diffuse cerebrospinal gliomatosis should be taken into consideration in the differential diagnosis of ALS.