Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal growth factors

E Canalis1, J Pash, S Varghese

  • 1Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT.

Critical Reviews in Eukaryotic Gene Expression
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antacid Abuse - A Case of Milk-Alkali Syndrome.

Irish medical journal·2026
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same journal

PFKFB2-Induced Glycolysis and Ferroptosis in Diabetic Nephropathy by HIF-1α.

Critical reviews in eukaryotic gene expression·2026
Same journal

LncRNA MANCR Acts as a ceRNA to Sponge MicroRNA-20a-5p and Upregulate GCNT4 to Suppress Angiogenesis in Colorectal Cancer.

Critical reviews in eukaryotic gene expression·2026
Same journal

Mechanistic Study of the Pink1/Parkin Signaling Pathway in Mitochondrial Dysfunction and Podocyte Injury.

Critical reviews in eukaryotic gene expression·2026
Same journal

Recent Advances in CRISPR-Cas Systems for Dengue Virus Detection.

Critical reviews in eukaryotic gene expression·2026
Same journal

A Lack of Association between Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer: A Comprehensive Meta-Analysis and Power Assessment.

Critical reviews in eukaryotic gene expression·2026
Same journal

Use of Rituximab in Pediatric Nephrology: A Bibliometric and Visualization Analysis from 2003 to 2024.

Critical reviews in eukaryotic gene expression·2025
See all related articles

Skeletal cells produce various growth factors that influence cell replication and function. These factors, including platelet-derived growth factor and fibroblast growth factor, play key roles in bone remodeling and cell differentiation.

Area of Science:

  • Cell biology
  • Biochemistry
  • Orthopedics

Background:

  • Growth factors are crucial polypeptides regulating cell replication and differentiation.
  • Skeletal cells synthesize diverse growth factors (e.g., PDGF, FGF, IGF, TGF-β, BMPs) acting in autocrine/paracrine manners.
  • Bone marrow cells produce cytokines involved in bone remodeling.

Purpose of the Study:

  • To elucidate the roles of various growth factors synthesized by skeletal cells.
  • To understand the mechanisms regulating skeletal growth factor activity.
  • To explore the impact of growth factors on osteoblast differentiation and osteoclast function.

Main Methods:

  • Review of literature on growth factor synthesis and function in skeletal cells.
  • Analysis of the known effects of specific growth factors (e.g., FGF, PDGF, IGF, TGF-β) on skeletal cell behavior.

Related Experiment Videos

  • Examination of regulatory mechanisms including synthesis, activation, binding proteins, and receptor interactions.

    • Main Results:

    • Platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs) are primarily mitogenic for skeletal cells.
    • Insulin-like growth factors (IGFs) and transforming growth factor beta (TGF-β) enhance osteoblast differentiated function.
    • Growth factors modulate osteoclast recruitment and function, influencing bone resorption.

    Conclusions:

    • Skeletal cells synthesize a complex array of growth factors and binding proteins essential for bone health.
    • Growth factor activity is tightly regulated at multiple levels, allowing modulation by external agents.
    • Understanding these growth factors is key to developing therapeutic strategies for skeletal disorders.