Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium antagonists in the elderly

J G Kelly1, K O'Malley

  • 1Elan Corporation plc, Monksland, Athlone, Westmeath, Ireland.

Drugs & Aging
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential impact of pembrolizumab in the adjuvant setting for intermediate-high risk and high risk kidney cancer.

Irish medical journal·2025
Same author

Assessment of two behavioural models (HBM and RANAS) for predicting health behaviours in response to environmental threats: Surface water flooding as a source of groundwater contamination and subsequent waterborne infection in the Republic of Ireland.

The Science of the total environment·2019
Same author

The Hidden Burden of Outpatient Repeat PSA Testing in a Prospective Cohort.

Irish medical journal·2017
Same author

Biliary excretion and enterohepatic recirculation of practolol in man.

Irish journal of medical science·2016
Same author

Factors Influencing Consumption of Fruits and Vegetables in Older Adults in New Orleans, Louisiana.

The journal of nutrition, health & aging·2016
Same author

The concept of primary prevention: Creating new paradigms.

The journal of primary prevention·2013
Same journal

Targeted Treatment for Hyperuricemia: The Drug Pipeline.

Drugs & aging·2026
Same journal

Efficacy and Safety of Ciprofol Versus Propofol for Anesthesia in Older Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Drugs & aging·2026
Same journal

Leveraging Real-World Data for Clinical Decision Making in Geriatric Oncology.

Drugs & aging·2026
Same journal

Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case-Control Study Among Community-Dwelling Older Adults.

Drugs & aging·2026
Same journal

Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies.

Drugs & aging·2026
Same journal

Development and Validation of Prescribing Appropriateness Criteria (PAC) for Sri Lankan Older Adults.

Drugs & aging·2026
See all related articles

Calcium antagonists effectively lower blood pressure with fewer side effects than other drugs. Elderly patients may require lower starting doses, but efficacy and safety are comparable across age groups.

Area of Science:

  • Pharmacology
  • Cardiology
  • Geriatrics

Background:

  • Calcium antagonists offer advantages over other antihypertensive agents, lacking metabolic, vascular, and respiratory adverse events.
  • New dihydropyridine calcium antagonists are emerging, expanding treatment options.

Purpose of the Study:

  • To evaluate the efficacy and safety of calcium antagonists in managing hypertension and angina, particularly in elderly individuals.
  • To compare the adverse effect profiles and antihypertensive effects of calcium antagonists in younger versus elderly patients.

Main Methods:

  • Literature review and analysis of clinical studies on calcium antagonists.
  • Pharmacokinetic and pharmacodynamic comparisons between different age groups.

Main Results:

Related Experiment Videos

  • Calcium antagonists are effective in reducing blood pressure and show comparable efficacy to other drug classes.
  • Elderly patients may experience higher plasma concentrations, necessitating lower initial dosages.
  • Adverse effect profiles are qualitatively and quantitatively similar in younger and older populations.

Conclusions:

  • Calcium antagonists are a viable option for hypertension and angina management, especially in elderly patients and those with comorbidities.
  • Their favorable safety profile, lacking adverse renal, respiratory, cardiovascular, metabolic, or peripheral vascular effects, makes them suitable for patients with complex conditions.