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Drug-induced mania in the elderly

L Ganzini1, S B Millar, J R Walsh

  • 1Psychiatry Service, Portland Veterans Affairs Medical Center, Oregon.

Drugs & Aging
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Drug-induced mania is a rare but serious complication in elderly individuals, often linked to corticosteroids and dopamine agonists. Discontinuing the offending drug typically resolves these manic episodes, with antipsychotics aiding recovery.

Area of Science:

  • Geriatric Medicine
  • Psychiatry
  • Clinical Pharmacology

Background:

  • Mania is an uncommon adverse effect of prescribed medications in the elderly population.
  • Corticosteroids and dopamine agonists are frequently implicated in drug-induced mania.
  • The role of antidepressants in precipitating mania versus unmasking latent bipolar disorder remains unclear.

Purpose of the Study:

  • To review the causes, clinical presentation, and management of drug-induced mania in older adults.
  • To highlight the potential behavioral and medical noncompliance issues associated with drug-induced mania.
  • To discuss treatment strategies, including drug discontinuation and pharmacological interventions.

Main Methods:

  • Literature review of case reports and studies on drug-induced mania in the elderly.

Related Experiment Videos

  • Analysis of the pharmacological mechanisms potentially leading to manic symptoms.
  • Synthesis of current treatment guidelines and evidence for managing manic episodes.

    • Main Results:

    • Drug-induced mania can manifest with poor judgment and risk-taking behaviors.
    • Most episodes are transient and resolve upon cessation of the causative agent.
    • Antipsychotic medications may expedite the resolution of drug-induced manic syndromes.

    Conclusions:

    • Discontinuation of the offending drug is the primary treatment for drug-induced mania.
    • Lithium may prevent corticosteroid-induced mania, but its efficacy in other drug-induced cases requires further investigation.
    • Early recognition and management are crucial for addressing drug-induced mania in elderly patients.