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Related Experiment Video

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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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Drug-induced mania in the elderly

L Ganzini¹, S B Millar, J R Walsh

¹Psychiatry Service, Portland Veterans Affairs Medical Center, Oregon.

|September 1, 1993

Summary

Drug-induced mania is a rare but serious complication in elderly individuals, often linked to corticosteroids and dopamine agonists. Discontinuing the offending drug typically resolves these manic episodes, with antipsychotics aiding recovery.

Area of Science:

Geriatric Medicine
Psychiatry
Clinical Pharmacology

Background:

Mania is an uncommon adverse effect of prescribed medications in the elderly population.
Corticosteroids and dopamine agonists are frequently implicated in drug-induced mania.
The role of antidepressants in precipitating mania versus unmasking latent bipolar disorder remains unclear.

Purpose of the Study:

To review the causes, clinical presentation, and management of drug-induced mania in older adults.
To highlight the potential behavioral and medical noncompliance issues associated with drug-induced mania.
To discuss treatment strategies, including drug discontinuation and pharmacological interventions.

Main Methods:

Literature review of case reports and studies on drug-induced mania in the elderly.

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Analysis of the pharmacological mechanisms potentially leading to manic symptoms.

Synthesis of current treatment guidelines and evidence for managing manic episodes.

Main Results:

Drug-induced mania can manifest with poor judgment and risk-taking behaviors.
Most episodes are transient and resolve upon cessation of the causative agent.
Antipsychotic medications may expedite the resolution of drug-induced manic syndromes.

Conclusions:

Discontinuation of the offending drug is the primary treatment for drug-induced mania.
Lithium may prevent corticosteroid-induced mania, but its efficacy in other drug-induced cases requires further investigation.
Early recognition and management are crucial for addressing drug-induced mania in elderly patients.