Drug-induced immune neutropenia

Drug-induced immune-mediated neutropenia is a serious complication of therapy with many different drugs. Its clinical presentation and outcome are highly variable. In addition to the drugs listed in this review it is likely that many other drugs also cause immune-mediated neutropenia but drug-dependent neutrophil antibodies were not reported because of the lack of widespread availability of testing. With the exception of quinine-dependent antibodies in three patients, the neutrophil antigens recognized by the drug-dependent antibodies are not known; however, the recent development of MAIGA assays will likely help identify the antigens other drug-dependent neutrophil antibodies recognize.