Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal function in sick, very low-birth-weight infants

M Vanpée1, U Ergander, P Herin

  • 1Department of Pediatrics, Karolinska Institute, St Görans Children's Hospital, Stockholm, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|September 1, 1993
PubMed
Summary

Mechanical ventilation and patent ductus arteriosus in premature infants significantly impair kidney function. These conditions reduce renal perfusion, leading to lower creatinine clearance and higher sodium excretion in vulnerable newborns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

p11 regulates the surface localization of mGluR5.

Molecular psychiatry·2015
Same author

Study of protein and RNA in dendritic spines using multi-isotope imaging mass spectrometry (MIMS).

Surface and interface analysis : SIA·2015
Same author

Alteration by p11 of mGluR5 localization regulates depression-like behaviors.

Molecular psychiatry·2015
Same author

Extremely preterm infants who are small for gestational age have a high risk of early hypophosphatemia and hypokalemia.

Acta paediatrica (Oslo, Norway : 1992)·2015
Same author

Predictors of sustained maternal milk feeds in extremely preterm infants.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same author

Preterm born 9-year-olds have elevated IGF-1 and low prolactin, but levels vary with behavioural and eating disorders.

Acta paediatrica (Oslo, Norway : 1992)·2014

Area of Science:

  • Neonatal Physiology
  • Pediatric Nephrology

Background:

  • Infants born with very low birth weight (gestational age < 30 weeks) exhibit significant renal immaturity.
  • Conditions like patent ductus arteriosus (PDA) and mechanical ventilation (MV) are common in these infants and may affect renal perfusion.

Purpose of the Study:

  • To investigate the impact of patent ductus arteriosus and mechanical ventilation on renal function in very low-birth-weight infants.
  • To determine if these interventions further compromise already immature renal function.

Main Methods:

  • A study involving 40 infants (4-28 days old) divided into four groups: Control (no PDA or MV), PDA+MV, PDA only, and MV only.
  • Assessment of renal function through creatinine clearance and fractional sodium excretion.
  • Measurement of mean arterial pressure and its correlation with renal function parameters.

Related Experiment Videos

Main Results:

  • Infants requiring mechanical ventilation and/or having a patent ductus arteriosus showed significantly lower creatinine clearances compared to controls.
  • Higher fractional sodium excretions were observed in the PDA+MV and MV groups.
  • Mean arterial pressure was lower in all intervention groups and correlated with reduced creatinine clearance.

Conclusions:

  • Both patent ductus arteriosus and mechanical ventilation, individually or combined, negatively impact renal function in immature, very low-birth-weight infants.
  • Reduced renal perfusion, indicated by lower mean arterial pressure, is a likely mechanism contributing to compromised renal function.
  • Clinical management of these infants should consider the potential renal effects of PDA and MV.