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Zinc supplementation impairs monocyte function

L Schlesinger1, M Arevalo, S Arredondo

  • 1Institute of Nutrition and Food Technology, University of Chile, Santiago.

Acta Paediatrica (Oslo, Norway : 1992)
|September 1, 1993
PubMed
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Zinc supplementation may negatively impact immune cell function in malnourished infants. Studies show reduced phagocytic and fungicidal activity in infants receiving fortified formula, suggesting potential impairment of monocyte function.

Area of Science:

  • Immunology
  • Nutritional Science
  • Pediatrics

Background:

  • Zinc plays a crucial role in various immune system functions.
  • Monocyte activity, including phagocytosis and metabolic functions, is vital for immune response.
  • Nutritional rehabilitation in infants withmarasmus requires careful consideration of micronutrient supplementation.

Purpose of the Study:

  • To investigate the impact of zinc supplementation on the immune function of blood monocytes in marasmic infants.
  • To evaluate the effects on phagocytic, fungicidal, and metabolic activities during nutritional rehabilitation.
  • To compare immune responses between infants receiving zinc-fortified formula and those receiving unfortified formula.

Main Methods:

  • A controlled, double-blind study involving 39 marasmic infants.

Related Experiment Videos

  • Two groups: one receiving zinc-fortified formula, the other receiving unfortified formula.
  • Assessment of phagocytic-fungicidal capacity, growth, and mineral status at admission, 60, and 105 days.

    • Main Results:

    • Zinc supplementation was associated with a decrease in the ability of monocytes to phagocytose Candida buds after 60 days.
    • An increase in depressed fungicidal activity was observed in the zinc-supplemented group after 105 days.
    • Infants receiving zinc-fortified formula experienced more frequent and prolonged impetigo episodes.

    Conclusions:

    • Zinc supplements at the Recommended Dietary Allowance (RDA) level may impair monocyte function in marasmic infants.
    • The findings suggest a potential negative impact of zinc fortification on immune defense mechanisms during nutritional rehabilitation.
    • Further research is needed to understand the optimal zinc levels for immune support in malnourished infants.