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Related Experiment Videos

Rats orally self-administer corticosterone

V Deroche1, P V Piazza, J M Deminière

  • 1Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259, Université de Bordeaux II, France.

Brain Research
|September 17, 1993
PubMed
Summary
This summary is machine-generated.

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Rats self-administered corticosterone solution orally, demonstrating its reinforcing properties. This effect was dose-dependent and persisted even when food access was altered, indicating corticosterone

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Corticosterone, a major rat glucocorticoid, influences drug reinforcement.
  • Glucocorticoids are often orally administered in humans.
  • Investigating oral corticosterone self-administration is relevant for human drug use.

Purpose of the Study:

  • To determine if corticosterone induces oral self-administration in rats.
  • To assess the dose-dependency of corticosterone's reinforcing effects.
  • To evaluate if corticosterone self-administration is independent of food intake.

Main Methods:

  • Rats chose between corticosterone solutions (25-100 µg/ml) and water with free food access.
  • Extinction and reversal tests were performed on the 100 µg/ml dose group.

Related Experiment Videos

  • A second experiment examined corticosterone intake independent of food availability.

    • Main Results:

    • Rats showed a dose-dependent preference for corticosterone over water.
    • Preference for corticosterone was extinguished but re-emerged upon reversal.
    • Rats consumed more corticosterone solution than water when food access was restricted.

    Conclusions:

    • Corticosterone exhibits reinforcing properties following oral administration in rats.
    • Oral corticosterone self-administration is a viable model for studying glucocorticoid reinforcement.
    • Findings suggest potential implications for understanding substance use disorders and stress-related behaviors.