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The interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance in rats
H Ohta1, K Matsumoto, H Watanabe
1Section of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Brain Research
|September 17, 1993
Abstract:
The interaction between cholinergic and beta-adrenergic systems on radial arm maze performance was investigated. Scopolamine significantly disrupted radial maze performance. Although neither propranolol (a centrally and peripherally acting beta-antagonist), nor atenolol (a peripherally acting beta 1-antagonist) affected the maze performance, both antagonists significantly augmented the scopolamine disruption. These results suggest the importance of the interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance.