Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer chemoprevention

L M Itri1

  • 1Robert Wood Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869-0670.

Cancer
|December 1, 1993
PubMed
Summary

Chemoprevention shows promise in reducing cancer incidence. Studies with 13-cis-retinoic acid, tamoxifen, and aspirin highlight the potential of targeted treatments and the need for rigorous trial design for effective cancer prevention strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Cancer-related anaemia requires higher doses of epoetin alfa than chronic renal failure replacement therapy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2001
Same author

Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition.

The oncologist·2000
Same author

Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Optimal hemoglobin levels for cancer patients.

Seminars in oncology·2000
Same author

Chemotherapy-induced anemia in adults: incidence and treatment.

Journal of the National Cancer Institute·1999

Area of Science:

  • Oncology
  • Preventive Medicine
  • Clinical Trials

Background:

  • Growing interest in chemoprevention for reducing cancer incidence.
  • Chemoprevention utilizes agents to prevent, reverse, or arrest the cancer process.

Purpose of the Study:

  • To review recent chemoprevention trial results.
  • To highlight the importance of study design in chemoprevention research.

Main Methods:

  • Review of findings from recent clinical trials.
  • Analysis of specific chemopreventive agents and their outcomes.

Main Results:

  • 13-cis-retinoic acid reversed oral leukoplakia and prevented second head and neck cancers.
  • Tamoxifen demonstrated efficacy in preventing breast cancer recurrence and new contralateral tumors.
  • Aspirin's effectiveness in reducing heart attacks is established; beta-carotene's cancer prevention role is under investigation.

Conclusions:

  • Chemoprevention strategies show significant potential in reducing cancer incidence.
  • Careful and rigorous trial design is crucial for generating reliable data in chemoprevention research.

Related Experiment Videos