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Therapy-related myelodysplastic syndrome. Two cytogenetically unrelated abnormal clones in a patient with multiple
D Abeliovich1, O Yehuda, S Ben-Neriah
1Department of Human Genetics, Mount Scopus, Hadassah University Hospital, Jerusalem, Israel.
Cancer Genetics and Cytogenetics
|October 15, 1993
Abstract:
A multiple myeloma patient presented for cytogenetic analysis at diagnosis of secondary MDS, which followed cytotoxic treatment including melphalan. Two abnormal unrelated clones were detected, one of them had 5q-, 7q- with clonal evolution of an additional aberration, t(12;13); in the second clone there was a translocation between the two homologues of chromosome 1 as the only aberration. We suggest that the clone with 5q- and 7q- represented the secondary MDS cells, whereas the abnormal clone with t(1;1) represented the plasmablasts of the multiple myeloma.