Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diet and carcinogenesis

A E Rogers1, S H Zeisel, J Groopman

  • 1Boston University School of Medicine, Department of Pathology, MA 02116.

Carcinogenesis
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coal combustion aerosols and sulfur dioxide: an interdisciplinary analysis.

Environmental science & technology·2012
Same author

A safety assessment of branched chain saturated alcohols when used as fragrance ingredients.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2010
Same author

A safety assessment of non-cyclic alcohols with unsaturated branched chain when used as fragrance ingredients: the RIFM expert panel.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2010
Same author

A toxicologic and dermatologic assessment of cyclic acetates when used as fragrance ingredients.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2008
Same author

A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2008
Same author

Role of registered nurses in error prevention, discovery and correction.

Quality & safety in health care·2008
Same journal

Correction to: Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB.

Carcinogenesis·2026
Same journal

Correction: Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.

Carcinogenesis·2026
Same journal

Wnt/β-catenin Signaling in Hepatocellular Carcinoma: A Major Context-Dependent Contributor to Resistance to Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors.

Carcinogenesis·2026
Same journal

TGF-β1 and TGF-β2 family members differentially modulate tumor initiation and invasiveness of primary liver cancer in a MMP14-dependent manner.

Carcinogenesis·2026
Same journal

MEK/ERK/RSK2 positive feedback loop modulates EMT to promote migration and invasion of triple-negative breast cancer through regulating GALNT5 mRNA stability.

Carcinogenesis·2026
Same journal

ADH1B-ALDH2 genotype combinations, Age-Related Risk, and Field Cancerization in Head and Neck and Upper GI Cancer Screening in 10,073 Alcohol-Dependent Men.

Carcinogenesis·2026
See all related articles

Dietary factors like calories, fats, vitamins, and fiber significantly influence rodent carcinogenesis. Further research is needed to translate these findings into human preventive medicine strategies.

Area of Science:

  • Nutritional Biochemistry
  • Cancer Research
  • Toxicology

Background:

  • Extensive research links diet to cancer development in laboratory rodents.
  • Epidemiological data and mechanistic studies highlight nutrient and non-nutrient food components' roles.

Purpose of the Study:

  • To review existing knowledge on dietary influences on rodent carcinogenesis.
  • To identify key nutrients and food components with mechanistic hypotheses for further investigation.
  • To explore the translational relevance of rodent findings to human cancer prevention.

Main Methods:

  • Review of experimental studies in laboratory rodents.
  • Analysis of epidemiological evidence and mechanistic hypotheses.
  • Evaluation of cellular, biochemical, and molecular effects of dietary factors.

Related Experiment Videos

Main Results:

  • Caloric restriction (>10%) consistently reduces rodent tumorigenesis, but optimal parameters for human application require definition.
  • Fat intake modifications show consistent effects in rodents, less so in humans, stimulating mechanistic research.
  • Lipotropes, vitamins, minerals, and fiber are valuable tools for studying carcinogenesis mechanisms, though isolated nutrient effects in rodents sometimes differ from human epidemiological expectations.
  • Non-nutrient food components and retinoids exhibit remarkable anticarcinogenic activity in specific models.

Conclusions:

  • Dietary components significantly impact rodent carcinogenesis, providing insights into fundamental cancer processes.
  • Translating rodent findings to human preventive medicine requires further research, particularly regarding specific nutrient combinations and whole foods.
  • Mechanistic studies are crucial for understanding diet-cancer interactions and advancing preventive strategies.