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[Acromegalic arthropathy]

G Perpignano1, E Cacace, A Beccaris

  • 1Istituto di Clinica Medica, Università degli Studi di Cagliari.

La Clinica Terapeutica
|July 1, 1993
PubMed
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Acromegaly, a condition caused by excess growth hormone (GH), can lead to joint problems resembling osteoarthritis. Early stages show cartilage thickening, while active disease may reduce bone density in the spine.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Radiology

Background:

  • Acromegaly results from excessive growth hormone (GH) production, typically due to a pituitary adenoma.
  • This condition can manifest with various musculoskeletal complications, impacting joints and bone metabolism.

Purpose of the Study:

  • To investigate the clinical, radiological, and metabolic manifestations of joint involvement in acromegalic patients.
  • To characterize the arthropathy associated with GH-producing pituitary adenomas.

Main Methods:

  • Clinical examination of six acromegalic patients (three males, three females).
  • Laboratory and instrumental tests, including radiological assessments.
  • Evaluation of bone metabolism and bone mass.

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Main Results:

  • All patients exhibited joint involvement with pain and crepitus, particularly in large weight-bearing joints.
  • Radiological findings mimicked osteoarthritis, with early stages showing cartilaginous hypertrophy and widened joint spaces.
  • Simultaneous increases in bone formation and resorption were observed; active acromegaly correlated with reduced lumbar spine bone mass.

Conclusions:

  • The arthropathy in acromegaly shares features with osteoarthritis but presents unique early radiological signs due to cartilage hypertrophy.
  • Bone metabolism is altered, with potential for bone mass reduction in active disease, especially in the lumbar spine.