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Protein glycosylation. Structural and functional aspects
1Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.
European Journal of Biochemistry
|November 15, 1993
Summary
Recent advances in glycoprotein knowledge enable biotechnological production for therapeutics. Glycoprotein structure, function, and carbohydrate roles in health and disease are reviewed.
Area of Science:
- Biochemistry
- Molecular Biology
- Biotechnology
Background:
- Significant progress in understanding glycoproteins over the past decade.
- Established foundation for biotechnological production of glycoproteins for therapeutic applications.
Purpose of the Study:
- To review recent advances in glycoprotein knowledge.
- To emphasize the structure and function of glycoproteins, excluding proteoglycans.
- To discuss the roles of carbohydrate units in glycoprotein properties and biological functions.
Main Methods:
- Survey of current methods for structural analysis of glycoproteins.
- Identification of novel carbohydrate-peptide linking groups.
- Analysis of mono- and oligo-saccharide constituents in glycoproteins.
Main Results:
- Glycoprotein carbohydrate units modulate physicochemical and biological properties.
- Carbohydrates act as recognition determinants between molecules, cells, and cell-cell interactions.
- Changes in glycoprotein carbohydrates are observed during differentiation, growth, and malignancy.
Conclusions:
- Glycoproteins play crucial roles in various biological processes, including health and disease.
- Understanding glycoprotein structure and function is key to their therapeutic development.
- Carbohydrate modifications in glycoproteins are significant indicators of physiological and pathological states.