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Protein glycosylation. Structural and functional aspects

H Lis1, N Sharon

  • 1Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.

European Journal of Biochemistry
|November 15, 1993
PubMed
Summary
This summary is machine-generated.

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Recent advances in glycoprotein knowledge enable biotechnological production for therapeutics. Glycoprotein structure, function, and carbohydrate roles in health and disease are reviewed.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Significant progress in understanding glycoproteins over the past decade.
  • Established foundation for biotechnological production of glycoproteins for therapeutic applications.

Purpose of the Study:

  • To review recent advances in glycoprotein knowledge.
  • To emphasize the structure and function of glycoproteins, excluding proteoglycans.
  • To discuss the roles of carbohydrate units in glycoprotein properties and biological functions.

Main Methods:

  • Survey of current methods for structural analysis of glycoproteins.
  • Identification of novel carbohydrate-peptide linking groups.
  • Analysis of mono- and oligo-saccharide constituents in glycoproteins.

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Main Results:

  • Glycoprotein carbohydrate units modulate physicochemical and biological properties.
  • Carbohydrates act as recognition determinants between molecules, cells, and cell-cell interactions.
  • Changes in glycoprotein carbohydrates are observed during differentiation, growth, and malignancy.

Conclusions:

  • Glycoproteins play crucial roles in various biological processes, including health and disease.
  • Understanding glycoprotein structure and function is key to their therapeutic development.
  • Carbohydrate modifications in glycoproteins are significant indicators of physiological and pathological states.