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Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats
Y Ishiyama1, K Kitamura, Y Ichiki
1First Department of Internal Medicine, Miyazaki Medical College, Japan.
European Journal of Pharmacology
|September 14, 1993
Abstract:
The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.