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Stereostructure and NMR characterization of the antibiotic candidin
J Pawlak1, P Sowiński, E Borowski
1Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
The Journal of Antibiotics
|October 1, 1993
Abstract:
The stereostructure of the heptaene macrolide antibiotic candidin was established on the basis of NMR studies: 13C, DQF-COSY, ROESY and C,H-COSY experiments. The absolute configuration of the candidin chiral centers were assigned as 3R, 5S, 10R, 11R, 13R, 15S, 16R, 17S, 19S, 34S, 35R, 36R and 37S.