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A case of herpes-associated erythema multiforme in a Japanese child
T Uemura1, M Nagayama, M Kawashima
1Department of Dermatology, Tokyo Women's Medical College, Japan.
Abstract:
A case of a five-year-old Japanese boy with herpes-associated erythema multiforme (HAEM) was reported. The patient had eleven recurrences of herpes labiaris within one year; four of these recurrences were accompanied by erythema multiforme. A study of the human leukocyte antigens revealed the presence of HLA-DQW3, which has been reported to be significantly frequent in Caucasian patients with HAEM. Oral administration of acyclovir at the onset of herpes labialis was effective in preventing HAEM. Early administration of oral steroids at the onset of HAEM also prevented its exacerbation.
Insights
A five-year-old boy experienced recurrent herpes-associated erythema multiforme (HAEM). Early treatment with acyclovir for herpes labialis and oral steroids for HAEM effectively prevented recurrences and exacerbations.
Area of Science:
- Dermatology
- Immunology
- Virology
Background:
- Herpes-associated erythema multiforme (HAEM) is a recurrent mucocutaneous condition.
- Understanding the genetic and clinical factors influencing HAEM is crucial for effective management.
Observation:
- A pediatric case of HAEM in a five-year-old Japanese boy with frequent herpes labialis recurrences was documented.
- The patient presented with four episodes of HAEM associated with herpes labialis within a year.
- Human leukocyte antigen (HLA) typing revealed the presence of HLA-DQW3, a marker previously associated with HAEM in Caucasian populations.
Findings:
- Oral acyclovir administered at the onset of herpes labialis effectively prevented HAEM.
- Early intervention with oral steroids during HAEM episodes mitigated disease exacerbation.
Implications:
- This case highlights the potential role of HLA-DQW3 in HAEM pathogenesis across different ethnicities.
- Early antiviral and anti-inflammatory treatment strategies can significantly improve outcomes for patients with recurrent HAEM.