Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in collagenous proteins and mechanical strength of distal colon after diverting colostomy in rats

P Kissmeyer-Nielsen1, H Christensen, S Laurberg

  • 1Department of Surgery L, University Hospital of Aarhus, Denmark.

International Journal of Colorectal Disease
|September 1, 1993
PubMed
Summary

A diverting colostomy in rats significantly weakened the left colon over 12 weeks. This study shows reduced weight, collagen, and biomechanical strength in defunctioned colons, impacting colon health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Norwegian midwifery students' perceptions and experiences of respectful and disrespectful maternity care - a qualitative study.

Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives·2026
Same author

LiVE-STROKE: live video from bystander to the medical dispatcher in potential stroke cases.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Motivations for Self-Harm in Young People and Their Correlates: A Systematic Review.

Clinical child and family psychology review·2025
Same author

Early mathematical models of COVID-19 vaccination in high-income countries: a systematic review.

Public health·2024
Same author

Protocol for a randomised controlled trial evaluating the effect of a CBT-I smartphone application (Sleep Ninja®) on insomnia symptoms in children.

BMC psychiatry·2023
Same author

Protocol for a randomised controlled trial evaluating the effectiveness of a CBT-based smartphone application for improving mental health outcomes in adolescents: the MobiliseMe study.

BMC psychiatry·2022

Area of Science:

  • Gastroenterology
  • Surgical Research
  • Biomedical Engineering

Background:

  • Diverting colostomy is a surgical procedure that reroutes fecal flow.
  • The effects of defunctioning the colon on its structural integrity are not fully understood.

Purpose of the Study:

  • To investigate the impact of a diverting colostomy on the weight, collagen content, and biomechanical strength of the left colon in a rat model.

Main Methods:

  • Female rats underwent either a diverting colostomy or a sham operation.
  • Colons were analyzed at 1, 2, 4, and 12 weeks post-surgery for dry weight, hydroxyproline (collagen marker), breaking strength, and tensile strength.

Main Results:

  • Defunctioned left colon showed significant decreases in dry weight (up to 52%) and hydroxyproline content (up to 40%) by 12 weeks compared to controls.

Related Experiment Videos

  • Biomechanical strength, including breaking strength (up to 25%) and tensile strength (up to 19%), was also significantly reduced in the defunctioned colon.
  • No significant changes were observed in the colon proximal to the colostomy site.

    • Conclusions:

    • Defunctioning the left colon in rats leads to a deterioration of its biomechanical properties.
    • This deterioration is attributed to reduced collagen content and quality in the defunctioned segment.