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A retrospective and an observational study with acyclovir

J P Malin1

  • 1Neurologische Klinik und Poliklinik, Ruhr-Universität Bochum, Germany.

Journal of Medical Virology
|January 1, 1993
PubMed
Summary
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Intravenous acyclovir (ACV) significantly reduced pain incidence in herpes zoster patients compared to controls. Oral ACV also decreased pain scores during treatment, showing its effectiveness in managing shingles pain.

Area of Science:

  • Virology
  • Immunology
  • Dermatology

Background:

  • Herpes zoster (shingles) commonly leads to post-herpetic neuralgia (PHN), a debilitating condition.
  • Antiviral medications like acyclovir (ACV) are used to treat herpes zoster.
  • The efficacy of ACV in preventing or reducing PHN requires further investigation.

Purpose of the Study:

  • To investigate the influence of intravenous acyclovir (ACV) on the incidence of post-herpetic neuralgia (PHN).
  • To assess the effectiveness of oral ACV in reducing pain during and after herpes zoster infection.

Main Methods:

  • Retrospective analysis of 23 patients receiving intravenous ACV versus 27 untreated controls, assessing PHN incidence 6-24 months post-herpes zoster.
  • Observational study of 15,831 non-hospitalized patients receiving oral ACV for 7 days, monitoring pain scores during treatment and PHN incidence at 3 months.

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Main Results:

  • Intravenous ACV significantly lowered the incidence of general and severe pain (P < 0.05) compared to controls.
  • Oral ACV treatment led to a decrease in pain scores from 2.3 to 0.9 within 7 days.
  • At 3 months post-herpes zoster, 16.95% of patients reported pain, with 2.1% experiencing continuous PHN.

Conclusions:

  • Intravenous acyclovir demonstrates a significant benefit in reducing pain associated with herpes zoster and potentially preventing PHN.
  • Oral acyclovir effectively alleviates pain during acute herpes zoster infection.
  • Further research may explore optimal ACV dosing and duration for PHN prevention.