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Related Experiment Videos

Decline in response to nicotine in aged rat striatum: correlation with a decrease in a subpopulation of nicotinic

D W Schulz1, G A Kuchel, R E Zigmond

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.

Journal of Neurochemistry
|December 1, 1993
PubMed
Summary

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Aging reduces the brain's response to nicotine, specifically impacting dopamine release in rats. This decline is linked to a significant decrease in a particular subtype of nicotinic receptors.

Area of Science:

  • Neuroscience
  • Aging Research
  • Neurochemistry

Background:

  • Cholinergic and dopaminergic systems undergo age-related changes in rodents and humans.
  • Limited data exists on aging effects on nicotinic cholinergic receptors and their functional correlation.

Purpose of the Study:

  • To investigate age-related changes in nicotinic receptor function and density.
  • To correlate functional declines with specific nicotinic receptor subtype alterations in aging rats.

Main Methods:

  • Used nicotine-stimulated dopamine efflux in striatal slices as a functional measure.
  • Performed binding studies with [3H]nicotine and 125I-neuronal bungarotoxin.
  • Employed quantitative autoradiography to map receptor distribution.

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Main Results:

  • Nicotine-stimulated dopamine efflux was significantly lower in aged rats compared to young rats.
  • Total striatal nicotinic receptors did not change with age.
  • An 80% decline was observed in a specific nicotinic receptor subpopulation recognized by nicotine and neuronal bungarotoxin, but not alpha-bungarotoxin.

Conclusions:

  • A specific subpopulation of nicotinic receptors declines with age in the rat brain.
  • This receptor subtype decrease may underlie functional deficits in motor and visual systems during aging.