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Related Experiment Videos

High-resolution computed tomography--physiologic correlation

E A Zerhouni1, C J Herold, R H Brown

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21205.

Journal of Thoracic Imaging
|January 1, 1993
PubMed
Summary
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High-resolution computed tomography (HRCT) offers a novel way to study lung responses to stimuli. This imaging technique uniquely identifies the location and regional differences of these physiologic changes.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Physiology

Background:

  • High-resolution computed tomography (HRCT) is emerging as a tool for investigating physiological and pharmacological responses in the lungs.
  • Previous research has primarily focused on airway responses to stimuli like histamine, saline, anesthesia, and hypoxia in animal models.

Purpose of the Study:

  • To present the rationale and current status of using physiologic HRCT.
  • To highlight HRCT's potential in studying bronchovascular and pulmonary responses.

Main Methods:

  • Investigation of airway responses using HRCT with various stimuli (histamine, saline, halothane, hypoxia).
  • Application of physiologic HRCT to study pulmonary circulatory responses to hypervolemia and hypoxia.

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Main Results:

  • HRCT can detect physiological responses in the lungs.
  • HRCT uniquely characterizes the site and locoregional differences of these responses, unlike other methods.

Conclusions:

  • Physiologic HRCT is a promising new method for studying lung physiology.
  • HRCT provides detailed, spatially resolved information on pulmonary and bronchovascular responses to various stimuli.