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High-resolution computed tomographic bronchiolography using perfluoroctylbromide (PFOB): an experimental model

R G Stern¹, M R Wolfson, J F McGuckin

¹Department of Diagnostic Imaging, Temple University Hospital, Philadelphia, Pennsylvania 19140.

Journal of Thoracic Imaging

|January 1, 1993

Summary

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Perfluoroctylbromide (PFOB) effectively visualizes small airways on CT scans, reaching centrilobular bronchioles. This liquid ventilatory agent shows promise for diagnosing small airway diseases.

Area of Science:

Pulmonary Medicine
Radiology
Biomedical Engineering

Background:

High-resolution computed tomography (HRCT) has limitations in visualizing small airway anatomy.
Current imaging techniques often fail to detail structures beyond the larger bronchi.

Purpose of the Study:

To evaluate perfluoroctylbromide (PFOB) as a contrast agent for computed tomography (CT).
To assess PFOB's ability to visualize small airway anatomy down to the centrilobular bronchiole level.

Main Methods:

A neonatal lamb heart-lung preparation was used.
HRCT scans were obtained before and after instilling PFOB into the trachea.
Mechanical ventilation and continuous positive airway pressure were applied.

Main Results:

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PFOB successfully filled and distended airways to the centrilobular bronchioles and their first-order branches.
Minimal spillage into air spaces allowed for excellent visualization of bronchiolar structures.
Detailed anatomic imaging of small airways was achieved.

Conclusions:

Perfluoroctylbromide (PFOB) is a suitable bronchographic contrast agent for CT.
PFOB's properties (gas exchange, low toxicity, radiopacity) make it ideal for small airway imaging.
PFOB holds significant potential for evaluating small airway diseases in conjunction with HRCT.