Apo A-IV: a new satiety signal

Chylomicrons have a suppressive effect on food consumption, which is attributed to apolipoprotein A-IV (apo A-IV). This protein is found in cerebrospinal fluid in vivo, and its infusion into the third ventricle of the brain reduces food intake. These findings suggest that this apolipoprotein operates through the central nervous system to regulate food intake.