Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Safety limits for nutrient intakes: concepts and data requirements

J N Hathcock1

  • 1Division of Science and Applied Technology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708.

Nutrition Reviews
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary supplements: what is in the public's best interest?

Science (New York, N.Y.)·2000
Same author

Over-the-counter chromium and renal failure.

Annals of internal medicine·1997
Same author

Vitamins and minerals: efficacy and safety.

The American journal of clinical nutrition·1997
Same author

Safety limits for nutrients.

The Journal of nutrition·1996
Same author

Applications of antioxidants in physiologically functional foods: safety aspects.

Critical reviews in food science and nutrition·1995
Same author

Marginal zinc status does not exacerbate pancreatic carcinogenesis associated with dietary soybean trypsin inhibitor concentrate in rats.

The Journal of nutrition·1994

Determining safe nutrient intake levels requires robust quantitative methods and clear toxicity data criteria. Establishing agreed-upon protocols enhances confidence in setting science-based nutritional guidelines.

Area of Science:

  • Nutritional Science
  • Toxicology
  • Risk Assessment

Background:

  • Quantitative methods for nutrient safety limits share conceptual links with chemical exposure limits and drug therapeutic indices.
  • Assessing the impact of fixed versus variable safety factors (SFs) is crucial for accurate limit calculation.

Purpose of the Study:

  • To evaluate quantitative methods for calculating safe nutrient intake limits.
  • To compare the outcomes of different safety factor (SF) approaches.

Main Methods:

  • Comparison of the Safety Research Method (SRM) and the Minimum Potency Method (MPM) for calculating safety limits.
  • Analysis of the implications of using fixed versus variable safety factors (SFs).

Main Results:

Related Experiment Videos

  • The SRM method yields lower nutrient intake limits compared to the MPM.
  • Neither method calculates limits below the Recommended Dietary Allowance (RDA), even for nutrients with narrow safety margins.

Conclusions:

  • Establishing clear acceptability criteria for toxicity data is paramount before calculated limits can inform policy.
  • A standardized formula with systematically varying SFs ensures safety limits do not fall below the RDA.
  • Objective safety limit identification and enhanced confidence in policy decisions depend on prior agreement on objectives, data criteria, and quantitative methods, supported by extensive toxicity data.