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Published on: February 8, 2019
Multiple central giant cell lesions with a Noonan-like phenotype
N J Betts1, J C Stewart, R J Fonseca
1Department of Oral and Maxillofacial Surgery, University of Pennsylvania School of Dental Medicine, Philadelphia.
Oral Surgery, Oral Medicine, and Oral Pathology
|November 1, 1993
Summary
Noonan syndrome patients can develop jaw giant cell lesions, a feature also seen in cherubism. This report details a case of Noonan-like/multiple giant cell lesion syndrome, discussing diagnosis and management.
Area of Science:
- Genetics and Developmental Biology
- Oral and Maxillofacial Surgery
- Pediatric Endocrinology
Background:
- Noonan syndrome is a genetic disorder with diverse clinical manifestations.
- Giant cell lesions of the jaws, resembling those in cherubism, have been observed in a subset of Noonan syndrome patients.
- The Noonan-like/multiple giant cell lesion syndrome is a recently recognized condition linking these features.
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