Related Experiment Videos
[Relation of angiographic changes to clinical data and risk factors in patients with arteriosclerosis obliterans]
Insights
Peripheral arterial obliterative disease shows significant arteriographical changes, particularly in the superficial femoral artery. Lesion severity correlates with age and clinical findings, with combined risk factors like smoking and hypertension showing statistical significance.
Area of Science:
- Vascular Medicine
- Radiology
- Cardiovascular Disease
Background:
- Peripheral arterial obliterative disease (PAOD) is a significant cause of morbidity.
- Arteriographical assessment is crucial for understanding disease extent and guiding treatment.
- Quantifying arteriosclerotic lesions aids in evaluating disease severity.
Purpose of the Study:
- To analyze arteriographical changes in patients with PAOD.
- To correlate these changes with clinical, laboratory data, and risk factors.
- To identify specific arterial segments and risk factor combinations associated with disease severity.
Main Methods:
- Arteriographical analysis of 90 extremities from 66 PAOD patients.
- Quantification of arteriosclerotic lesions using a scoring system.
- Evaluation of pelvic, femoral, and crural arterial regions.
- Correlation with clinical data (walking distance, Doppler index) and risk factors (smoking, hypertension, diabetes, hyperlipidemia).
Main Results:
- Pathomorphological changes found in 433 of 720 arteries (11.8% plaque, 22.3% stenosis, 26% occlusion).
- Superficial femoral artery most frequently affected (89%); femoral region showed most severe radiological changes.
- Lesion degree and extent correlated with patient age.
- Morphological severity aligned with clinical findings.
- Individual risk factors showed no consistent correlation, but combinations (heavy smoking with hypertension/diabetes) were significant.
Conclusions:
- Arteriographical findings in PAOD are age-dependent and correlate with clinical severity.
- Specific arterial segments (superficial femoral artery, femoral region) are predominantly affected.
- Combined risk factors, particularly smoking with hypertension or diabetes, significantly worsen radiological changes in PAOD.
Abstract:
The arteriographical changes of 66 patients with peripheral arterial obliterative disease and the relationship between the observed alterations and certain clinical and laboratory data as well as some risk factors were analysed. A score system was used to quantify the arteriosclerotic lesions. The arterial alterations of the examined 90 extremities were studied in the pelvic (common and external iliac arteries), femoral (common, superficial, deep femoral and popliteal arteries) and crural (anterior and posterior tibial arteries) regions. Pathomorphological changes in 433 of the investigated 720 arteries were shown, from among them plaque in 11.8%, stenosis in 22.3%, total occlusion in 26% were proved. Most frequently (89%) the superficial femoral artery was affected. As to the single vessels, the superficial femoral and posterior tibial arteries, while among the zones the femoral region proved to be most serious radiologically. The degree and extent of vessel lesions were related to age. The morphological severity was basically concordant with the results of clinical investigations (walking distance, ergometry, Doppler index). The separately examined risk factors (smoking, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia) were not related consequently to the radiological changes, but in certain combinations, as heavy smoking with hypertension and heavy smoking with diabetes, the relationship proved to be statistically significant.