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Trophic effects on testes in paraplegics

P A Chapelle1, A Roby-Brami, M Jondet

  • 1Service de Rééducation Neurologique, Hôpital Raymond Poincaré, Garches, France.

Paraplegia
|September 1, 1993
PubMed
Summary

Spinal cord injuries affecting the T10-L2 region in paraplegic patients correlate with specific testicular germinal cell abnormalities. This suggests the spinal lesion may damage testicular sympathetic nerves, contributing to atrophy.

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Area of Science:

  • Reproductive medicine
  • Neuroscience
  • Urology

Background:

  • Paraplegia resulting from spinal cord injury can impact various bodily functions.
  • The sympathetic nervous system plays a role in testicular function.

Purpose of the Study:

  • To investigate the relationship between spinal cord lesions and testicular abnormalities in paraplegic patients.
  • To explore potential mechanisms, including nerve damage, contributing to testicular dysfunction.

Main Methods:

  • Testicular biopsies were performed on 23 paraplegic patients with complete spinal cord sections.
  • Hormone profiles were analyzed.
  • Lesion locations were correlated with biopsy findings.

Main Results:

  • Hormone profiles were generally normal across all patients.
  • Patients with spinal lesions involving the T10-L2 metameres exhibited distinct germinal cell abnormalities.
  • Testicular atrophy was observed, potentially linked to the spinal lesion.

Conclusions:

  • Complete spinal cord sections, particularly those affecting T10-L2, are associated with specific testicular germinal cell abnormalities.
  • Damage to the sympathetic innervation of the testis by the spinal lesion is a potential contributing factor to testicular atrophy in paraplegic patients.

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