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The changes of c-fos mRNA expression in the protein kinase C activated-osteoblastic MC3T3-E1 cells cultured in a
A Matsumoto1, Y Deyama, M Okitsu
1Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|January 1, 1993
Abstract:
The effect of phorbol 12-myristate 13-acetate (TPA) on the c-fos mRNA expression in the osteoblastic MC3T3-E1 cells cultured in a low-calcium environment was examined. The c-fos mRNA expression in MC3T3-E1 cells with the treatment of TPA was enhanced under the low-calcium environment. This fact suggests that TPA induced-protein kinase C enhancement produced the increase of c-fos mRNA expression, and that protein kinase C may be intimately involved in c-fos mRNA expression.