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Related Experiment Videos

Possible interaction between warfarin and fluconazole

K R Gericke1

  • 1Division of Clinical Pharmacy, University of California, San Francisco 94143-0662.

Pharmacotherapy
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Fluconazole, an antifungal, may increase warfarin's effect, raising bleeding risk. This drug interaction is potentially more significant in patients with reduced kidney function.

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Area of Science:

  • Pharmacology
  • Internal Medicine

Background:

  • Fluconazole is a triazole antifungal agent.
  • It has a low affinity for human cytochrome P-450 enzymes.
  • Fluconazole is not expected to interact with drugs metabolized by the cytochrome P-450 system, such as warfarin.