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The influence of antigen organization on B cell responsiveness
M F Bachmann1, U H Rohrer, T M Kündig
1Department of Pathology, University of Zürich, Switzerland.
Science (New York, N.Y.)
|November 26, 1993
Abstract:
The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.