[Interactions between diclofenac and glibenclamide]

24 diabetic patients, well controlled on Glibenclamid and a standard diet, were randomised for a doubleblind study with Diclofenac und placebo. After 3 days during which the fasting blood sugar and urine sugar were determined, 12 patients received Diclofenac, 12 patients placebo. Determinations of blood and urine sugar of the following 4 days and comparison of the two groups did not reveal any differences. Mean values of blood sugar of the first three days compared with the blood sugar of days of medication did not show significant changes. Considering this investigation it can be assumed that there is no interaction between Glibenclamid and Diclofenac.