Specificity of thymidylate synthase inactivation by 4,5-bisubstituted dUMP analogues

Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells.

Biochemical pharmacology·2010

Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in Trichinella muscle larvae.

Parasitology·2005

Trichinella spiralis thymidylate synthase: cDNA cloning and sequencing, and developmental pattern of mRNA expression.

Parasitology·2004

Interaction of thymidylate synthase with the 5'-thiophosphates, 5'-dithiophosphates, 5'-H-phosphonates and 5'-S-thiosulfates of 2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine.

Biological chemistry·2001

5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.

Journal of medicinal chemistry·2000

Trichinella spiralis and Trichinella pseudospiralis: developmental patterns of enzymes involved in thymidylate biosynthesis and pyrimidine salvage.

Parasitology·2000

Hematological and biochemical alterations in patients with suspected COVID-19 infection with negative and positive RT-PCR swabs.

Acta biochimica Polonica·2026

Urinary tract infections in diabetes: clinical significance and management approaches.

Acta biochimica Polonica·2026

Gap junction protein connexin 36 proteostatic mechanisms in photoreceptor cells subjected to excitotoxic stress.

Acta biochimica Polonica·2026

Optimization of a TEEDA-based initiation system for SDS-PAGE.

Acta biochimica Polonica·2026

Correction: Value evaluation of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques in patients with acute cerebral infarction.

Acta biochimica Polonica·2026

The yields of nucleic acids and proteins extracted from various murine tissue types.

Acta biochimica Polonica·2026

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Journal of computational chemistry·2026

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

Biophysical journal·2026

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

[Construction and application of organoid models in traditional Chinese medicine research].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

Journal of biomedical informatics·2026

Related Experiment Videos

Specificity of thymidylate synthase inactivation by 4,5-bisubstituted dUMP analogues

Related Concept Videos

Isolation of a homogeneous preparation of human thymidylate synthetase from HeLa cells.

Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in Trichinella muscle larvae.

Trichinella spiralis thymidylate synthase: cDNA cloning and sequencing, and developmental pattern of mRNA expression.

Interaction of thymidylate synthase with the 5'-thiophosphates, 5'-dithiophosphates, 5'-H-phosphonates and 5'-S-thiosulfates of 2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine.

5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.

Trichinella spiralis and Trichinella pseudospiralis: developmental patterns of enzymes involved in thymidylate biosynthesis and pyrimidine salvage.

Hematological and biochemical alterations in patients with suspected COVID-19 infection with negative and positive RT-PCR swabs.

Urinary tract infections in diabetes: clinical significance and management approaches.

Gap junction protein connexin 36 proteostatic mechanisms in photoreceptor cells subjected to excitotoxic stress.

Optimization of a TEEDA-based initiation system for SDS-PAGE.

Correction: Value evaluation of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques in patients with acute cerebral infarction.

The yields of nucleic acids and proteins extracted from various murine tissue types.

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

[Construction and application of organoid models in traditional Chinese medicine research].

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

Related Experiment Videos

Specificity of thymidylate synthase inactivation by 4,5-bisubstituted dUMP analogues

Related Concept Videos

Related Articles