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[Mitotic index of intraepithelial lymphocytes in children with celiac disease. Retrospective study]
M T García de Dávila1, S De Rosa
1Servicio de Patología, Hospital Nacional de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
Acta Gastroenterologica Latinoamericana
|January 1, 1993
Abstract:
The mitotic activity of epithelial lymphocytes was determined in 69 jejunal biopsies performed in 23 children with celiac disease. The mitotic index (MI) exceeded 0.2% in 46 biopsies obtained in untreated celiac and during acute gluten challenge. In the 23 biopsies made during the period of gluten restriction the mitotic index fell down under 0.2%. This retrospective study confirm the reproducibility of the method proposed by Marsh. The high mitotic index in the first biopsy may be useful to reduce in the future the multiple biopsies currently necessary for the diagnosing celiac disease.