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Peripheral antinociceptive effects of morphine after burn injury
S Møiniche1, J B Dahl, H Kehlet
1Department of Anaesthesiology, Hvidovre University Hospital, Copenhagen, Denmark.
Acta Anaesthesiologica Scandinavica
|October 1, 1993
Abstract:
In a double-blind study, 2 mg of morphine in saline, or saline only, was given subcutaneously into a second-degree bilateral leg-burn injury in 12 volunteers. Heat-pain thresholds and pressure-pain thresholds were significantly increased by local morphine administration. These results confirm experimental data demonstrating a peripheral antinociceptive effects of opioids in inflamed tissue.