[Determination of the optical purity of praziquanamine by reversed phase HPLC after derivatization with GITC]

The enantiomers of praziquanamine were separated by reversed phase HPLC after derivatization with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylisothiocyanate (GITC). The determination of the optical purity of praziquanamine was successfully achieved. This method was applied to the determination of the optical purity of d- and l-praziquanamines.