Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sugar malabsorption in functional bowel disease: clinical implications

F Fernández-Bañares1, M Esteve-Pardo, R de Leon

  • 1Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

The American Journal of Gastroenterology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health-related quality of life analysis of the LEAP-002 study of lenvatinib plus pembrolizumab versus lenvatinib as first-line treatment for advanced hepatocellular carcinoma.

ESMO open·2025
Same author

Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Assessment of activated gut-homing CD8<sup>+</sup> T cells in blood by flow cytometry during a 3-day gluten challenge.

Methods in cell biology·2023
Same author

The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022.

ESMO open·2023
Same author

Corrigendum to "Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up": [Annals of Oncology 29 suppl. 4 (2018) v238-iv255].

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Correction to: “Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up".

Annals of oncology : official journal of the European Society for Medical Oncology·2019

Sugar malabsorption, particularly of lactose and fructose, is linked to abdominal distress in functional bowel disease patients. Dietary restriction of offending sugars improved symptoms in 40% of those studied.

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Clinical Nutrition

Background:

  • Functional bowel disease (FBD) affects a significant portion of the population, often presenting with unexplained gastrointestinal symptoms.
  • Carbohydrate malabsorption is frequently suspected in patients with FBD, but its direct link to symptom development requires further investigation.

Purpose of the Study:

  • To investigate the relationship between sugar malabsorption and the development of clinical symptoms in patients diagnosed with functional bowel disease.
  • To assess the impact of dietary interventions on symptom severity in FBD patients with identified sugar malabsorption.

Main Methods:

  • Twenty-five FBD outpatients and 12 healthy controls underwent breath-hydrogen testing after oral sugar loads (lactose, fructose, sorbitol, sucrose).

Related Experiment Videos

  • Symptom severity was recorded post-challenge, and the effect of a sugar-restricted diet versus a low-fat diet was evaluated.

    • Main Results:

    • High prevalence of sugar malabsorption (over 90%) was observed in both FBD patients and controls.
    • FBD patients reported significantly higher symptom scores after lactose and fructose/sorbitol malabsorption compared to controls and sucrose malabsorption.
    • Hydrogen production capacity was elevated in FBD patients, and symptom improvement occurred in 40% of patients on a sugar-restricted diet.

    Conclusions:

    • Sugar malabsorption, particularly of lactose and fructose, is associated with increased symptom severity in a subset of functional bowel disease patients.
    • Dietary restriction of identified offending sugars can lead to clinical improvement in some individuals with FBD.