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Long-term outcome in 87 patients with low-grade soft-tissue sarcoma
S G Marcus1, M J Merino, E Glatstein
1Surgery Branch, National Cancer Institute, Bethesda, Md.
Archives of Surgery (Chicago, Ill. : 1960)
|December 1, 1993
Summary
Low-grade soft-tissue sarcomas generally have excellent survival rates, particularly when not in the retroperitoneum. Adjuvant radiation and clear surgical margins minimize recurrence risk for these tumors.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Low-grade soft-tissue sarcomas (LGSTS) require understanding of long-term outcomes.
- Prognostic factors for LGSTS are crucial for patient management.
Purpose of the Study:
- To detail the long-term clinical outcomes of patients diagnosed with low-grade soft-tissue sarcoma.
- To identify predictive factors influencing the prognosis of LGSTS.
Main Methods:
- Retrospective chart review and multivariate analysis.
- Study conducted at a large research hospital and referral center.
- Included patients treated between 1975 and 1990 with confirmed LGSTS diagnosis.
Main Results:
- Nonretroperitoneal LGSTS demonstrated excellent overall survival.
- Positive surgical margins, history of recurrence, and lack of adjuvant radiation increased local recurrence risk.
- Retroperitoneal LGSTS showed higher local recurrence rates and significantly poorer overall survival.
Conclusions:
- LGSTS are associated with excellent overall survival, especially nonretroperitoneal types.
- Negative surgical margins and adjuvant radiation therapy significantly reduce local recurrence risk.
- Most recurrences of LGSTS are manageable with subsequent therapies.