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Systemic lupus erythematosus in a rhesus macaque
1Department of Rheumatology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas.
Arthritis and Rheumatism
|December 1, 1993
Abstract:
We describe the clinical course and histopathologic findings in a rhesus macaque (Macaca mulatta) which developed a systemic inflammatory disorder resembling systemic lupus erythematosus (SLE). The manifestations of the SLE included antinuclear antibody, hemolytic anemia, membranoproliferative glomerulonephritis, and arthritis. To our knowledge, spontaneously occurring SLE has not previously been described in nonhuman primates.