Regulation of Na+,K(+)-ATPase gene expression: a model to study terminal differentiation
1Department of Paediatrics, St. Göran's Children's Hospitals, Karolinska Institutet, Stockholm, Sweden.
Abstract:
This review focuses on the ontogeny of factors involved in the transcriptional regulation of Na+,K(+)-ATPase expression. The Na+,K(+)-ATPase enzyme is of vital importance for cell function. It is likely that the limited availability of Na+,K(+)-ATPase in infant tissue is the major limiting factor for adaptation to extra-uterine life in several organs. The factors regulating Na+,K(+)-ATPase gene transcription in infancy are discussed. Special emphasis is given to the role of circulating hormones such as glucocorticoids and thyroxine.
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