Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macrophage-Cryptococcus interactions

S M Levitz1

  • 1Boston University School of Medicine, Boston University Hospital, Massachusetts.

Immunology Series
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Macrophages are key immune cells fighting fungal infections like cryptococcosis. Their effectiveness against Cryptococcus neoformans depends heavily on their diverse characteristics and interactions, requiring further research into human conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens.

Clinical and experimental immunology·2019
Same author

Fungal Recognition and Host Defense Mechanisms.

Microbiology spectrum·2017
Same author

Determination of the pH of the Cryptococcus neoformans vacuole.

Medical mycology·2002
Same author

Does amoeboid reasoning explain the evolution and maintenance of virulence factors in Cryptococcus neoformans?

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Cryptococcus neoformans: intracellular or extracellular?

Trends in microbiology·2001
Same author

Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Transmembrane and intracellular signaling events in lipopolysaccharide-stimulated macrophages.

Immunology series·1994
Same journal

Lentivirus infection of macrophages.

Immunology series·1994
Same journal

The macrophage and HIV-1.

Immunology series·1994
Same journal

Macrophages and Blastomyces dermatitidis.

Immunology series·1994
Same journal

Macrophage-Aspergillus interactions.

Immunology series·1994
Same journal

Interaction of Histoplasma capsulatum yeasts and conidia with human and animal macrophages.

Immunology series·1994
See all related articles

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Macrophages are diverse immune cells influenced by origin, location, and activation state.
  • These cells interact with various other cells within and outside the immune system.
  • Understanding these variables is crucial for studying macrophage functions.

Purpose of the Study:

  • To review the influence of macrophage heterogeneity on interactions with Cryptococcus neoformans.
  • To highlight the significant but undefined role of macrophages in cryptococcosis host defense.
  • To identify challenges in researching macrophage-C. neoformans interactions in human physiological states.

Main Methods:

  • Literature review and data synthesis on macrophage characteristics and their impact on C. neoformans interactions.
  • Analysis of existing evidence supporting the role of macrophages in cryptococcosis.

Related Experiment Videos

  • Identification of research gaps and future directions.

    • Main Results:

    • Macrophage heterogeneity significantly impacts interactions with Cryptococcus neoformans.
    • Circumstantial evidence strongly suggests a major role for macrophages in host defense against cryptococcosis.
    • The precise nature and extent of macrophage contribution to cryptococcosis defense remain undefined.

    Conclusions:

    • Macrophage characteristics critically influence host defense against Cryptococcus neoformans.
    • Further research is needed to precisely define the role of macrophages in cryptococcosis.
    • Future studies should aim to replicate human physiological and pathological conditions for accurate insights.