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[Anatomo-functional changes in the cavernous body in the elderly]

D Fontana¹, L Rolle, A Lacivita

¹Dipartimento di Scienze Cliniche e Biologiche dell'Università di Torino.

Archivio Italiano Di Urologia, Andrologia : Organo Ufficiale [Di] Societa Italiana Di Ecografia Urologica E Nefrologica

|October 1, 1993

Summary

As men age, collagen increases in the corpora cavernosa, while smooth muscle and elastic fibers decrease. This age-related histological change impacts erectile function and blood flow dynamics.

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Area of Science:

Urology
Histology
Physiology

Context:

The corpora cavernosa's histological structure undergoes age-related changes.
Understanding these alterations is crucial for addressing erectile dysfunction.

Purpose:

To describe the primary histological changes in the corpora cavernosa with aging.
To correlate these histological changes with functional consequences on erection.

Summary:

Aging leads to a progressive increase in collagen fibers within the corpora cavernosa.
Concurrently, there is a decrease in smooth muscle and elastic fibers in this tissue.
These histological shifts are implicated in altered hemodynamic events during erection.

Impact:

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Provides insight into the pathophysiology of age-related erectile dysfunction.
Highlights the structural basis for impaired erectile hemodynamics.
Informs potential therapeutic strategies targeting tissue remodeling.