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Primary generalized osteoarthritis and bone mass

L D Hordon1, S P Stewart, P R Troughton

  • 1Rheumatology and Rehabilitation Research Unit, University of Leeds.

British Journal of Rheumatology
|December 1, 1993
PubMed
Summary

Osteoarthritis (OA) is linked to higher bone density in post-menopausal women, particularly at the spine and forearm. This finding suggests bone mass may play a role in OA development.

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Area of Science:

  • Orthopedics
  • Rheumatology
  • Endocrinology

Background:

  • The relationship between osteoarthritis (OA) and bone mass remains debated.
  • Previous studies have yielded conflicting results regarding bone mineral density (BMD) in OA patients.

Purpose of the Study:

  • To investigate bone mineral density (BMD) and total body bone mineral (TBBM) in post-menopausal women with primary generalized OA.
  • To compare bone mass measurements in OA patients with those of healthy controls.

Main Methods:

  • Dual-energy X-ray absorptiometry (DXA) was used to measure BMD at the hip and spine, and TBBM.
  • Single photon absorptiometry measured BMD at the distal forearm.
  • Data from 20 post-menopausal women with OA were compared to 89 healthy controls.

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Main Results:

  • Osteoarthritic women exhibited significantly higher spinal BMD (P < 0.001) and distal forearm BMD (P < 0.05).
  • Total body bone mineral (TBBM) was also significantly increased in the OA group (P < 0.01).
  • No significant difference in BMD was observed at the femoral neck between groups. Obesity did not explain these bone mass differences.

Conclusions:

  • Post-menopausal women with generalized OA demonstrate increased bone mass at the spine and forearm.
  • These findings contribute to the understanding of the complex interplay between bone density and osteoarthritis.
  • Further research is warranted to explore the influence of mobility on these associations.