Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melanoma predilection for the lower limbs of women compared with men.

Archives of dermatological research·2022
Same author

The influence of FIBTEM and EXTEM clotting times on the diagnostic accuracy of ROTEM<sup>®</sup> sigma identification of hypofibrinogenaemia during cardiac surgery.

Anaesthesia·2022
Same author

Digital rectal examination in palpable rectal cancer: expert panel consensus on key elements and analysis of a case series.

The British journal of surgery·2021
Same author

A standardized approach in robotic abdominoperineal excision - a video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
Same author

European consensus on the standardization of robotic total mesorectal excision for rectal cancer.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2018
Same author

An audit of the diagnostic accuracy of rotational thromboelastometry for the identification of hypofibrinogenaemia and thrombocytopenia during cardiopulmonary bypass.

Anaesthesia and intensive care·2018

Related Experiment Video

Updated: Jul 27, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Lymph node metastases in early rectal cancer

S P Huddy1, E M Husband, M G Cook

  • 1Colorectal Research Unit, Basingstoke District Hospital, UK.

The British Journal of Surgery
|November 1, 1993
PubMed
Summary

Local excision for early rectal tumors can be an alternative to major surgery. However, 20% of patients with tumors confined to the bowel wall had lymph node metastases, indicating a need for careful patient selection.

More Related Videos

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jul 27, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pathology

Background:

  • Local excision of early rectal tumors offers a less invasive alternative to major resection.
  • Minimally invasive approaches aim to reduce morbidity, mortality, and the need for permanent stomas.

Purpose of the Study:

  • To determine the incidence of lymph node metastases in rectal tumors confined to the bowel wall.
  • To assess the risk of metastasis in early-stage rectal cancer suitable for local excision.

Main Methods:

  • Retrospective review of 454 rectal excision specimens.
  • Analysis of tumor characteristics and lymph node involvement.

Main Results:

  • 20% of patients (22/109) with tumors confined to the bowel wall had lymph node metastases.
  • 3 out of 27 patients with tumors not penetrating the submucosa also had nodal metastases.
  • Less differentiated tumors showed a higher likelihood of metastasis.

Conclusions:

  • A significant proportion of early rectal tumors exhibit lymph node metastasis, even when locally confined.
  • Tumor differentiation is a key factor in predicting nodal spread.
  • Careful patient selection is crucial for local excision to avoid understaging and inadequate treatment.