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Prognostic value of DNA analysis in colorectal carcinoma
T C Böttger1, D Potratz, M Stöckle
1Department of General and Abdominal Surgery, Johannes Gutenberg-Universität Mainz, Germany.
Background:
Reported experiences regarding the prognostic significance of DNA content in colorectal carcinoma have been a matter of controversy.
Methods:
DNA analysis with image cytometry was performed in 137 patients with colorectal cancer. Only patients who had resection without tumor residual and who did not die postoperatively as a consequence of the operation were entered in the study. At the time of DNA analysis, neither the histomorphologic data nor the relapse-free survival time of the patients were known.
Results:
In this investigation the DNA content of tumor cells had no univariate or multivariate influence on the relapse-free survival time. The prognosis was dependent on the tumor localization, depth of tumor infiltration, lymph node metastasis, and grade.
Conclusions:
DNA content provides no additional prognostic information in colorectal carcinoma.