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Malignant atrophic papulosis. A report of two cases with altered fibrinolysis and platelet function
F J Vázquez-Doval1, F Ruiz de Erenchun, J A Páramo
1Department of Dermatology, University Clinic of Navarra, University of Navarra, Pamplona, Spain.
Clinical and Experimental Dermatology
|September 1, 1993
Abstract:
Malignant atrophic papulosis is a systemic vaso-occlusive disorder characterized by typical skin lesions. We report two new cases with impairment of blood fibrinolytic activity and alterations in platelet function. The first case showed an increase in plasminogen activator inhibitor-1 (PAI-1) activity, and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen. The impairment of blood fibrinolytic activity and platelet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis.