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Updated: Oct 12, 2026

High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii
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Schistosoma mansoni: genetic complementation analysis shows that two independent hycanthone/oxamniquine-resistant

L Pica-Mattoccia1, L C Dias, R Moroni

  • 1Institute of Cell Biology, Rome, Italy.

Experimental Parasitology
|December 1, 1993
PubMed

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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
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