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Electrophoretically defined myosin heavy chain patterns of single human muscle spindles
F Pedrosa-Domellöf1, B Gohlsch, L E Thornell
1Department of Anatomy, University of Umeå, Sweden.
FEBS Letters
|December 6, 1993
Abstract:
At least four myosin heavy chain (MHC) isoforms were separated by SDS-PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHCemb. A faint band, moving slightly faster than MHCemb, most likely represents a neonatal/fetal MHC isoform. A prominent band, moving between the latter and the slow isoform is suggested to represent a hitherto unidentified, spindle-specific MHC isoform, MHCif.