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Effect of catalytically active recruited crystallins on lens metabolism
M C Reddy1, B Groth-Vasselli, A Sharon
1Department of Physiology, New Jersey Medical School, Newark 07103.
FEBS Letters
|December 6, 1993
Abstract:
The impact on duck lens metabolism of recruited epsilon-crystallin/LDH-B4 and tau-crystallin/enolase was investigated by NMR spectroscopy. A comparison of the duck lens metabolite profile with that of the calf in which recruited crystallins are absent revealed significant increases in ATP, alpha-glycerophosphate (alpha-GP) and pyridine dinucleotide concentrations. The alterations in the concentrations of ATP and alpha-GP appear to be related to both the high concentration of NAD and the elevated reduced to oxidized NADH/NAD+ ratio.